How Genetic Play a Role in Cancer Risk


Cancer is a serious disease and the second leading cause of death globally. It is estimated that one in nine people develop cancer. Cancer is a genetic disorder in that a change in the DNA code of some genes predisposes to unregulated cell division and cancer.  DNA changes in the cancer cells cannot pass to the children, but if there are genetic changes. in the parent egg or sperm cells that predispose to cancer, these can be passed down from parents to offspring. About 10% of cancers occur because of these inherited DNA genetic changes.

As per the report, India registered around 12 lakh active cases of cancer and around 9.3 lakh deaths in 2019. The Indian rate of cancer is found to be 14,61, 427. This means one in nine people is likely to develop the cancer disease during his/her lifetime. Some of the factors that contribute towards cancer rise are increased alcohol, sedentary lifestyle, smoking, late pregnancy, etc. Multiple mechanisms include inherited genetic mutations, environmental factors and errors in cell division.

Exploring the article will highlight the link between cancer and genetics as well role in the development of cancer risk.

Link Between Genes and Cancer

Our body has billions of cells and each cell has DNA, the instruction manual of the cell. This is present in the 20,000-odd genes in our cells. Genes are responsible for sending instructions to each cell on how to grow, divide, and function. In cancerous cells, this process of controlled cell division and growth is disturbed because of gene mutations alluded to above.

These gene mutations can be acquired due to environmental factors or random cell division errors. Additionally, these can be inherited from the parent germ cells.

Role of Genetics in Cancer Development

Genetic changes can increase the risk of cancer as they alter the working behaviour of cells. All cancer-causing DNA changes occur in the genes, that carry the instruction to make proteins or specialised RNA such as MicroRNA. Scientists stated that there must be changes in more than DNA to turn healthy cells into cancerous cells. However, inherited cancer-related genes also need other additional changes to develop cancer or may never develop changes to increase the risk of cancer.

For more information on the role of genetics in cancer development, book an appointment at Sir Ganga Ram Hospital, where the top medical expert will provide detailed advice on your query. You can also get personalized attention from the best doctors.

Comments

Post a Comment

Popular posts from this blog

Understanding Diabetes in Children: Causes, Symptoms, and Management

Image
  Diabetes is a chronic condition that affects millions of people worldwide, including children. While Type 1 diabetes is more common in children, Type 2 diabetes is also becoming increasingly prevalent due to lifestyle factors. Managing diabetes in children requires a multidisciplinary approach involving parents, healthcare professionals, and educators. Causes of Diabetes in Children: Type 1 diabetes is an autoimmune disease in which the immune system attacks and destroys insulin-producing cells in the pancreas. The exact cause of Type 1 diabetes is unknown, but genetic and environmental factors are believed to play a role. Children with a family history of Type 1 diabetes are at a higher risk of developing the condition.   On the other hand, Type 2 diabetes is often linked to lifestyle factors such as poor diet, lack of physical activity, and obesity. With the rise in childhood obesity rates, more children are being diagnosed with Type 2 diabetes at a younger age. Insulin resis
Read more

Managing Orthopaedic Problems in Winter

Image
Winter is a season that can pose several problems for many individuals, especially for those who suffer from orthopaedic problems. The cold weather and slippery conditions of the winter months can cause much discomfort to people, mainly older adults. They experience difficulties navigating these conditions, leading to joint pain and stiffness, back pain, muscle strains, and an increased risk of fractures. However, there are ways to understand and manage these problems that can help reduce the risks and prevent further muscle damage. This helps keep the joints and muscles warm, preventing stiffness and pain. Maintaining a healthy diet and daily exercise routine is also crucial during winter. Eating a proper diet with foods rich in vitamin D and calcium can help strengthen bones and muscles, reducing the risk of fractures. Another important aspect of managing  joint replacement  problems during winter is to be mindful of one's surroundings. It is essential to take extra care while
Read more